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Freeze dryer does not damage the experimental sample
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Freeze-drying, also known as lyophilization, is a process where a water-containing substance is first frozen into a solid state, then the moisture is removed through sublimation—directly turning from solid to gas without passing through the liquid phase. In compressed air drying, freeze-drying reduces the temperature of the air to cause moisture to condense. The working principle of a freeze dryer (cold dryer) is similar to that of a refrigerator. Compressed air passes through a cold pipe, lowering its temperature to meet the required drying standards.
In China, freeze-drying technology has seen some development, especially in the pharmaceutical industry, where it is widely used for injectable drugs. This method enhances drug quality and extends shelf life, benefiting both medical professionals and patients. However, there are limited types of lyophilized drugs, with high costs and less advanced processes. In traditional Chinese medicine, some herbs like ginseng and Cordyceps are lyophilized, but many proprietary medicines have not yet adopted this technique, leading to a gap compared to foreign countries.
Japan has made significant progress by integrating Western and traditional Chinese medicine, improving the tanning methods of herbal remedies and enabling them to be produced as injections or tablets. This approach has also helped address some previously incurable conditions. Freeze-drying holds great potential in biotechnology, particularly in preserving biological materials such as serum, plasma, vaccines, enzymes, antibiotics, and more. It is also used in the long-term storage of tissues and organs.
Currently, freeze-drying equipment is mainly divided into intermittent and continuous types, ranging from small-scale to large-scale units. Intermittent systems are ideal for multi-variety, small-batch production, offering flexibility and ease of control. However, they tend to have lower efficiency due to time-consuming loading and unloading processes. Continuous systems, on the other hand, are better suited for large-volume, single-product production and offer automation advantages. Although costlier, they improve productivity and reduce manual intervention.
With the completion of GMP certification, domestic freeze-drying equipment has entered a modernization phase, featuring reliable performance, stable operation, and functions like online cleaning and steam sterilization. While foreign equipment offers more specifications, energy efficiency, and advanced continuous systems, domestic manufacturers are steadily catching up.
To ensure product quality and energy efficiency, hybrid systems like spray freeze-drying are often used. Looking ahead, improving freeze-drying efficiency, reducing drying time, and saving energy will be key goals for the industry.
At Shanghai Xinzhuang, we believe that quality is essential for survival, technology drives growth, management ensures efficiency, and service builds trust. Every project, every piece of equipment, and every process is handled with precision and care. Our commitment to excellence and customer satisfaction has earned us a strong reputation in the market.
We welcome your inquiries and look forward to supporting you with our professional team and advanced technology. Discover the power of freeze-drying with Shanghai Xinzhuang Instrument Co., Ltd.
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