HER2 accurate detection to achieve individualized treatment of breast cancer

HER2 accurate detection to achieve individualized treatment of breast cancer

In recent years, breast cancer has become one of the fastest-rising malignant tumors in China, and the incidence rate is increasing rapidly at an annual growth rate of 3% to 4%. At the press conference of the "Importance of High-Quality HER2 Testing for Individualized Breast Cancer Treatment" held on October 26, the participating experts unanimously called on all breast cancer patients to establish awareness of HER2 testing and actively cooperate with doctors to carry out the correct Diagnosis and prevention of breast cancer HER2 patients are missed or misdiagnosed.

HER2, also known as human epidermal growth factor receptor-2, is an important prognostic factor for breast cancer. Sun Qiang, Director of Breast Surgery, Peking Union Medical College Hospital, said that among all breast cancer patients, 2 to 3 of every 10 people are HER2 positive patients. Compared with other breast cancer patients, the tumors of HER2 positive breast cancer patients are more malignant. It progresses faster, is more likely to relapse and metastasize, and the patient's disease-free survival period is significantly shortened. It is "the most dangerous breast cancer."

"If you only receive conventional comprehensive treatment, the survival time of HER2-positive breast cancer patients is only half of that of HER2-negative patients. If the HER2 status can be determined early and targeted treatment is used, the survival chance of HER2-positive patients may be close to HER2-negative patients. Sun Qiang said.

According to Chen Jie, deputy director of Peking Union Medical College Hospital, the most common method used for clinical detection of HER2 is fluorescence in situ hybridization (FISH), but FISH technology cannot store the results for a long time, the operation is difficult, the time is long, and it must be Doctors observe the morphology of tissue cells in the dark field, which leads to great difficulty in quality assurance and promotion.

Chen Jie believes that the solution to this problem is to achieve full automation of pathological testing, minimize manual operations, and thus provide patients with more accurate and faster HER2 testing. According to reports, the SISH technology used by the Roche Diagnostics BenchMark series of fully automatic immunohistochemical detection platforms does not require manual operation and can be read with a conventional microscope, which is more sensitive.

"The fully automatic immunohistochemical detection and molecular detection platform reduces the manual operation time by 80%, which can greatly shorten the detection cycle. More importantly, the platform greatly improves the consistency and accuracy of the test results, so that patients can get Timely and effective treatment reduces the treatment delay and resource waste caused by improper treatment. "Chen Jie said.

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