The ultrasonic cell crusher is composed of an ultrasonic generator and a transducer

Brief introduction of ultrasonic cell crusher Ultrasound is an elastic mechanical wave in the material medium, it is a form of wave, so it can be used to detect physiological and pathological information of the human body, both diagnostic ultrasound. At the same time, it is also a form of energy. When ultrasound reaches a certain dose, it can cause changes in the function and structure of the organism through the interaction between them, that is, the biological effect of ultrasound. The effects of ultrasound on cells mainly include thermal effects, cavitation effects and mechanical effects. The thermal effect is that when ultrasound is propagated in the medium, the frictional force hinders the molecular vibration caused by the ultrasound, which converts part of the energy into local hyperthermia (42-43 ℃), because the critical lethal temperature of normal tissue is 45.7 ℃, while Normal tissues have high sensitivity, so at this temperature, the metabolism of tumor cells is impaired, and the synthesis of DNA, RNA, and protein is affected, thereby killing cancer cells while normal tissues are not affected. The cavitation effect is the formation of cavitation in the organism under ultrasound irradiation. With the vibration of the cavitation and its violent explosion, it produces mechanical shear pressure and turbulence, which causes the tumor to bleed and disintegrate the tissue to cause necrosis. In addition, the instantaneous high temperature (about 5000 ° C) and high pressure (up to 500 × 104Pa) are generated when the cavitation bubble breaks, which can thermally dissociate water vapor to produce .OH radicals and .H atoms, which are produced by Atomic redox reactions can lead to polymer degradation, enzyme inactivation, lipid peroxidation, and cell killing. The mechanical effect is the primary effect of ultrasound. During the propagation of ultrasound, the medium particles alternately compress and stretch to form a pressure change, causing damage to the cell structure. The intensity of the killing effect is closely related to the frequency and intensity of ultrasound.

Basic Principles of Ultrasonic Cell Crusher Ultrasonic Cell Crusher utilizes the dispersion effect of ultrasonic waves in the liquid to cause cavitation of the liquid, thereby breaking the solid particles or cell tissue in the liquid. The ultrasonic cell crusher is composed of two parts: an ultrasonic generator and a transducer. The ultrasonic generator converts the city power into 18-21KHz alternating power supply to the transducer. The barium zirconate titanate piezoelectric vibrator is the heart of the transducer. It deforms elastically with the alternating voltage at a frequency of 18-21KHz, and the transducer then longitudinally vibrates. The vibration wave generates a cavitation effect through a titanium alloy horn immersed in a biological solution, and excites the biological particles in the medium to vibrate violently.

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