Discover the "remains" of nano-biological effects Peroxidase is an important metalloprotease, widely used in chemical, food, pesticide, medical, environmental and industrial fields. Yan Xiyun found that peroxidase can be a better substitute-iron oxide has catalytic properties similar to peroxidase at the nanoscale, and its catalytic efficiency, reaction kinetic parameters and catalytic mechanism are similar to those of natural enzymes. This discovery surprised her and her partner. For common sense, iron oxide is considered to be an inert substance and cannot have the biological effect of enzymes. When she told the discovery to the academician of the Chinese Academy of Sciences and the well-known nano-scientist, the other party humorously reminded her: "Aren't you cheating?" Be aware that scientific researchers will inevitably draw some wrong conclusions due to improper experimental design or improper operation. In order to confirm the above findings, she asked 3 students to do the blind test back to back, and repeated the experiment under the same conditions, and they got the same result. After intensive research, she found that the above-mentioned catalytic reaction occurred on the surface of magnetic nanoparticles and was affected by many factors, among which Fe2 + / Fe3 + conversion was the key, and the smaller the particle size, the higher the catalytic efficiency. The core problem. More importantly, Yan Xiyun found that its catalytic efficiency is high, and it is stable, economical, and mass-producible. These characteristics not only make up for the weak and unstable weaknesses of natural enzymes, but also overcome the problem of low catalytic efficiency of simulated enzymes in the past. Based on this, she proposed the concept of nano-simulated enzymes and published them in the journal Nature-Nanotechnology, which attracted attention in the fields of medicine, physics, chemistry, and materials science, and was considered an important breakthrough in the field of mimic enzyme research. Based on the discovery of nano-simulated enzymes, she invented a variety of new technologies and applied them in the fields of medical imaging, environmental management, and pesticide detection. In particular, she used nano-simulated enzymes to develop new technologies for tumor diagnosis. Through cooperation with clinicians, nearly 1,000 tumor specimens have been tested. The results are consistent with conventional immunohistochemistry. Its sensitivity and specificity are high, and it is simple and fast. In particular, it has broken through the limitation of immunohistochemistry relying on expensive antibodies . In order to convert nano-simulated enzymes into tumor diagnostic reagents, Yan Xiyun specially invited Zhang Dexi, who has many years of experience in reagent development and industrialization, to join the team. Prior to this, Zhang Dexi had been a senior executive in a reagent company for many years, and was familiar with the difficulties in the transformation of reagent scientific research achievements and breakthrough methods. At present, Zhang Dexi is working with the team members to gradually promote the industrial transformation of nano-simulated enzyme tumor diagnostic reagents. Development of new anticancer drugs The other half of Yan Xiyun's dream is to develop a new drug. How difficult is it to develop new drugs? An industry insider once said that during the "Eleventh Five-Year" and "Twelfth Five-Year", the state invested hundreds of millions of yuan, the aircraft carrier was launched, and the spacecraft went to heaven, but where are our new drugs? Yan Xiyun, who is of medical background, feels that she should strive to turn her research results into new drugs. She is willing to give it a try and find a breakthrough in cancer treatment. Tumor development depends on blood vessels to provide nutrition and metastasis pathways. Blocking the supply of blood vessels is a new strategy for tumor treatment. The key is to find tumor blood vessel markers. Avastin is currently the only antibody drug in the world that blocks tumor blood vessels, and its target is vascular endothelial growth factor (VEGF). Yan Xiyun discovered for the first time in the world that CD146 is a new target for tumor blood vessels. Its antibodies can block tumor blood vessels and inhibit the growth and metastasis of various cancers such as liver cancer, pancreatic cancer, and melanoma. "magazine. She then demonstrated that CD146 antibody, siRNA and CD146EC-KO knockout all inhibit tumor angiogenesis. These have become the initial experimental evidence to propose a new target for CD146 tumor vasculature and are widely cited by colleagues. With the deepening of research, Yan Xiyun found that CD146 is currently the most important co-receptor for the angiogenic factor VEGF receptor. Both CD146 antibody and CD146EC-KO knockout inhibit VEGF-induced signaling and angiogenesis. In particular, the combined use of CD146 antibody can significantly improve the efficacy of pancreatic cancer and melanoma that are not originally sensitive to Avastin, and reduce its side effects. In addition, she also proved the molecular mechanism of CD146 to promote tumor metastasis, developed CD146 humanized antibody drugs, and completed the work of antibody humanization and affinity maturation. The MRCT, an internationally renowned antibody drug research and development institution, has undergone rigorous inspections and concluded that the mechanism of action of this antibody is clear, and it is expected to become a new tumor antibody drug, and signed a cooperation agreement with the Institute of Biophysics. She was therefore recommended as the person in charge of the major project of "tumor antibody drugs" in the national "863" plan. Regarding the achievements in scientific research, Yan Xiyun repeatedly stated that this was the result of teamwork. And she is very focused on cultivating young scientists. In particular, she introduced to the reporter Wang Fei, a young member of the antibody drug development team. He has just started to take on a heavy responsibility in the team just after graduating with a doctorate. 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