Premium Microfiber Fabric Rolls,Soft Cleaning Cloth Bulk Material,Durable Microfiber Upholstery Fabric,Eco-Friendly Non-Woven Microfiber Roll NINGBO JENNY IMPORT & EXPORT CO.,LTD , https://www.jenny-china.com
Shanghai Institute of Biosciences found that interleukin-17 can enhance the immunosuppressive function of mesenchymal stem cells
In a recent breakthrough, the prestigious international journal *Cell Death and Differentiation* published a groundbreaking study led by researchers from the Institute of Health Sciences at the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. The paper, titled *"Interleukin-17 Enhances Immunosuppression by Mesenchymal Stem Cells,"* sheds new light on how interleukin-17 (IL-17) enhances the immunosuppressive capabilities of mesenchymal stem cells (MSCs). This discovery has significant implications for understanding the roles of IL-17 and MSCs in inflammatory diseases and tumors, offering promising avenues for future therapeutic strategies.
Mesenchymal stem cells are a versatile type of stem cell found in various tissues throughout the body. They are not only capable of differentiating into multiple cell types but also possess unique immunomodulatory properties that set them apart from other stem cells. These cells have the ability to migrate toward injury sites, where they interact with the local inflammatory environment. This interaction plays a crucial role in shaping the immune microenvironment, making MSCs essential players in the development of immune-related disorders, as well as in regenerative medicine and stem cell therapy.
The immunoregulatory functions of MSCs are typically activated by inflammatory signals such as interferon-gamma (IFNγ) and tumor necrosis factor-alpha (TNFα). In this study, Dr. Han Xiaoyan and her team discovered that IL-17, a key pro-inflammatory molecule, significantly boosts the immunosuppressive effects of MSCs when combined with IFNγ and TNFα. This enhancement occurs through the upregulation of inducible nitric oxide synthase (iNOS), an enzyme critical for immune modulation.
To validate their findings, the researchers used a liver injury model induced by concanavalin A (Con A). The results showed that MSCs treated with both IL-17 and inflammatory cytokines were able to completely reverse liver damage. Further experiments revealed that IL-17 exerts its effect by reducing the levels of AUF1, a protein responsible for degrading iNOS mRNA. By stabilizing iNOS expression, IL-17 effectively amplifies the immunosuppressive potential of MSCs.
This research marks the first comprehensive exploration of how IL-17 regulates the immunosuppressive function of MSCs. It not only deepens our understanding of the mechanisms underlying MSC-based immunotherapy but also opens new possibilities for developing more effective treatments for immune-related diseases. The study was supported by several major funding programs, including the Science and Technology Special Project of the Chinese Academy of Sciences, the "973" National Key Basic Research Program, the Chinese Academy of Sciences Knowledge Innovation Project, and the National Natural Science Foundation of China.
Microfiber fabric is a new textile material with high technology and high added value. It is mainly made of very fine fibers (usually between 0.1 microns and a few microns in diameter) and has the following characteristics:
​1. ** High water absorption ** : Microfiber fabric because of its small fiber diameter, can absorb a lot of water, several times higher than ordinary cotton fabric.
​2. ** Soft and comfortable ** : Due to the large gap between the fibers, the touch is very soft, good air permeability, high comfort.
​3. Strong wear resistance ** : The fiber structure of microfiber fabrics is tight, the wear resistance is far more than that of traditional fiber materials, and it is not easy to pilling.
​4. ** Anti-wrinkle ** : Fabric is not easy to produce wrinkles, easy to take care of.
​5. ** Antistatic ** : Due to its special chemical and physical properties, microfiber fabrics can effectively reduce the generation of static electricity.
​6. ** Environmental protection ** : In the production process, microfiber fabrics are environmentally friendly and have less impact on the environment.
​Microfiber fabrics are widely used in clothing, household goods, medical and other fields, such as the production of high-end clothing, bedding, baby diapers, surgical gowns, etc., because of its excellent performance and welcomed by the market.